Sublocade is a long-acting injectable form of buprenorphine used to treat moderate to severe opioid use disorder (OUD). It works by steadily releasing medication over time to reduce cravings and withdrawal symptoms. Sublocade is ideal for individuals who are already stable on buprenorphine and want a convenient, once-monthly treatment option.
If you or a loved one is dealing with opioid addiction, finding a treatment that supports long-term recovery is critical. Sublocade is an FDA-approved medication-assisted treatment (MAT) designed specifically for opioid use disorder. It’s not a quick fix, but it can be a powerful part of a recovery plan—offering consistent medication delivery, reduced cravings, and freedom from daily pills or films. At Revival Recovery Center, we’re dedicated to helping people understand their options, and Sublocade is one more tool in the fight against addiction.
In this article, we’ll break down how Sublocade works, who it’s meant for, and what you need to know if you’re considering it as part of your treatment plan.
What exactly is Sublocade, and how does it work?
Sublocade is a prescription medication used in the treatment of moderate to severe opioid use disorder. It’s an extended-release injection that delivers buprenorphine—a partial opioid agonist—over the course of a month. Buprenorphine works by binding to opioid receptors in the brain, reducing cravings and preventing withdrawal without producing the intense high of full opioids.
Once injected, Sublocade forms a gel-like depot under the skin that slowly releases medication into the bloodstream. This steady release ensures consistent levels of buprenorphine, which helps stabilize brain chemistry and support recovery. Unlike daily oral forms like Suboxone, Sublocade only needs to be administered once a month by a healthcare professional.
Related: Transitioning from Suboxone to Sublocade: What Patients Need to Know
Who qualifies for Sublocade treatment?
Sublocade isn’t for everyone, but it can be a good fit for people who have already begun their recovery journey. To qualify, a person must first be stabilized on a daily oral form of buprenorphine, typically for at least seven days. This is to ensure their body tolerates the medication and to reduce the risk of withdrawal or complications.
Ideal candidates include:
- Individuals who have trouble maintaining daily medication adherence
- People seeking a lower risk of misuse or diversion
- Patients who prefer not to take daily doses
- Those committed to a long-term recovery program
It’s important to consult with a medical provider to determine eligibility, as other health factors and treatment goals need to be considered.
Related: What Is Sublocade? A Long-Acting Treatment for Opioid Use Disorder
What are the benefits of Sublocade compared to other forms of buprenorphine?
Sublocade offers several advantages over traditional daily medications like Suboxone or generic buprenorphine-naloxone. For many people, the consistency and convenience can make a major difference in recovery success.
Key benefits include:
- Once-monthly dosing: No need to remember a daily pill or film
- Steady medication levels: Helps reduce cravings and withdrawal more effectively
- Lower misuse potential: No take-home doses means less chance of misuse or diversion
- Supports structure and accountability: Regular monthly clinic visits encourage ongoing care
- Discreet and private: No visible medication packaging at home or work
These benefits can help patients maintain stability and reduce the risk of relapse—especially in early or high-risk phases of recovery.
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What are the risks and side effects of Sublocade?
While Sublocade is generally safe and well-tolerated, it does come with potential risks and side effects. As with any medication, it’s important to discuss these with your healthcare provider before starting treatment.
Common side effects may include:
- Injection site pain, swelling, or redness
- Constipation
- Nausea or vomiting
- Headache
- Fatigue
- Liver enzyme changes
In rare cases, more serious side effects can occur, such as allergic reactions or liver problems. It’s also important to avoid other sedating substances—especially alcohol or benzodiazepines—while on Sublocade, as combining these can increase the risk of respiratory depression.
Regular monitoring and open communication with your care team will help manage any concerns.
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How is Sublocade administered and what should I expect?
Sublocade is administered by a licensed healthcare provider as a subcutaneous injection (under the skin), usually in the abdominal area. It’s given once every 26 to 30 days, and each dose provides a full month of buprenorphine.
Here’s what to expect:
- Initial stabilization – You’ll start on a daily buprenorphine product for at least 7 days.
- Transition to Sublocade – Once stable, your provider will schedule your first injection.
- Monthly appointments – You’ll return every month for follow-up care and your next dose.
- Monitoring – Your progress will be tracked to ensure the medication is working effectively.
- Support services – Most clinics, like Revival Recovery Center, offer counseling and therapy alongside MAT.
The injection itself takes only a few minutes, and most people are able to return to normal activity shortly after.
How does Sublocade support long-term recovery?
Sublocade plays a powerful role in supporting lasting recovery from opioid addiction. Its once-monthly dosing helps reduce the daily struggle of managing cravings and withdrawal, which often leads to relapse. By offering consistent, controlled medication, Sublocade allows people to focus on therapy, work, family, and rebuilding a healthy life.
Additionally, Sublocade minimizes the stigma and stress associated with daily dosing, which can feel like a constant reminder of addiction. Patients often report feeling more “normal” and less burdened by their treatment plan. Combined with counseling and support services, Sublocade can be an essential part of a comprehensive recovery strategy.
At Revival Recovery Center, we view Sublocade not as a cure, but as a vital tool in a personalized, holistic treatment plan that promotes long-term healing.
Quick Answers About Sublocade
Is Sublocade the same as Suboxone?
No. Both contain buprenorphine, but Suboxone is a daily film or tablet, while Sublocade is a monthly injection.
Is Sublocade covered by Medicaid?
In many cases, yes. Medicaid often covers Sublocade as part of medication-assisted treatment for opioid use disorder, though prior authorization may be required. Revival Recovery Center assists patients with insurance verification and approval.
Can I stop taking Sublocade once I feel better?
Sublocade should only be discontinued under medical supervision as part of a structured taper or transition plan.
Where is Sublocade treatment provided?
Sublocade injections must be administered in person by a licensed healthcare provider. Revival Recovery Center provides Sublocade treatment at its Highland, Michigan location, with additional care coordination and follow-up support as part of treatment planning.
Does Sublocade get you high?
No. Sublocade doesn’t produce a high when used as directed and is designed to reduce cravings, not create euphoria.
Can someone switch from Suboxone to Sublocade?
Yes. Many patients begin treatment with daily buprenorphine, such as Suboxone, and transition to Sublocade after a stabilization period. This transition is carefully managed by a medical provider to ensure safety and effectiveness.
Revival Recovery Center, located in Highland, Michigan, provides compassionate, evidence-based treatment for opioid use disorder, including Sublocade therapy. Lisa Perna, a board-certified nurse practitioner specializing in addiction medicine and behavioral health, leads our team with a personalized, whole-person approach to recovery. Whether you’re local or need flexibility, we also offer virtual appointments in Brighton, Michigan to make care more accessible.
Contact Revival Recovery Center today to learn if Sublocade is right for you or a loved one.
